尚青,郑和堂,闫丽,史永利

• 1:河北科技大学化学与制药工程学院
• 2:河北科技大学化学与制药工程学院
• 3:河北科技大学化学与制药工程学院
• 4:河北科技大学化学与制药工程学院 河北石家庄050018

摘要(Abstract)：

聚合物纳米粒子是一种新型的药物载体,具有小粒子特征,可以穿越生物膜屏障, 到达传统药物无法到达的人体特定部位,建立起新的给药途径;聚合物载体的多变性又可赋予药物许多新的特点,因而引起广泛关注。按预聚物分散和单体聚合2种方法,介绍了载药聚合物纳米粒子的制备方法以及粒子的表面修饰;描述了粒子的粒度、形貌、相对分子质量、Zeta电位及热性能的表征方法;介绍了其应用现状;对聚合物纳米粒子载药体系的发展方向提出了建议。

关键词(KeyWords)： 聚合物纳米粒子;药物载体;制备方法;性能;应用

Abstract:

Keywords:

基金项目(Foundation): 河北省科技攻关项目(03215101D)

作者(Author): 尚青,郑和堂,闫丽,史永利

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